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Original Article
- Quilty Lesions in the Endomyocardial Biopsies after Heart Transplantation
- Haeyon Cho, Jin-Oh Choi, Eun-Seok Jeon, Jung-Sun Kim
- J Pathol Transl Med. 2019;53(1):50-56. Published online December 26, 2018
- DOI: https://doi.org/10.4132/jptm.2018.11.30
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- 5 Web of Science
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Abstract
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Supplementary Material - Background
The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients.
Methods
A total of 1190EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions,acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy wasdiagnosed by computed tomography coronary angiography. Clinical information, including thepatients’ survival was retrieved by a review of medical records.
Results
Eighty-eight patients(75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellularrejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patientsdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesionsfrom transplantation was longer than that of acute cellular rejections. We found a significant associationbetween Quilty lesions and cardiac allograft vasculopathy. No significant relationship wasfound between Quilty lesions and the patients’ survival.
Conclusions
Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection. -
Citations
Citations to this article as recorded by
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American Journal of Transplantation.2020; 20(12): 3308. CrossRef
- The human myocardium harbors a population of naive B-cells with a distinctive gene expression signature conserved across species
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